Issue 8, 2022

Application of nanotechnology in the diagnosis and treatment of acute pancreatitis

Abstract

Acute pancreatitis (AP) is a common digestive system disease. The severity of AP ranges from mild edema in the pancreas to severe systemic inflammatory responses leading to peripancreatic/pancreatic necrosis, multi-organ failure and death. Improving the sensitivity of AP diagnosis and developing alternatives to traditional methods to treat AP have gained the attention of researchers. With the continuous rise of nanotechnology, it is being widely used in daily life, biomedicine, chemical energy and many other fields. Studies have demonstrated the effectiveness of nanotechnology in the diagnosis and treatment of AP. Nanotechnology has the advantages of simplicity, rapidity and sensitivity in detecting biomarkers of AP, as well as enhancing imaging, which helps in the early diagnosis of AP. On the other hand, nanoparticles (NPs) have oxidative stress inhibiting and anti-inflammatory effects, and can also be loaded with drugs as well as being used in anti-infection therapy, providing a new approach for the treatment of AP. In this article, we elaborate and summarize on the potential of nanoparticles for diagnostic and therapeutic applications in AP from the current reported literature and experimental results to provide useful guidelines for further research on the application of nanotechnology.

Graphical abstract: Application of nanotechnology in the diagnosis and treatment of acute pancreatitis

Article information

Article type
Minireview
Submitted
10 Janv. 2022
Accepted
16 Marts 2022
First published
19 Marts 2022
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2022,4, 1949-1961

Application of nanotechnology in the diagnosis and treatment of acute pancreatitis

W. Jia, L. Xu, W. Xu, M. Yang and Y. Zhang, Nanoscale Adv., 2022, 4, 1949 DOI: 10.1039/D2NA00020B

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