Issue 4, 2022

Tumor-targeted nano-delivery system of therapeutic RNA

Abstract

The birth of RNAi technology has pioneered actionability at the molecular level. Compared to DNA, RNA is less stable and therefore requires more demanding delivery vehicles. With their flexible size, shape, structure, and accessible surface modification, non-viral vectors show great promise for application in RNA delivery. Different non-viral vectors have different ways of binding to RNA. Low immunotoxicity gives RNA significant advantages in tumor treatment. However, the delivery of RNA still has many limitations in vivo. This manuscript summarizes the size-targeting dependence of different organs, followed by a summary of nanovesicles currently in or undergoing clinical trials. It also reviews all RNA delivery systems involved in the current study, including natural, bionic, organic, and inorganic systems. It summarizes the advantages and disadvantages of different delivery methods, which will be helpful for future RNA vehicle design. It is hoped that this will be helpful for gene therapy of clinical tumors.

Graphical abstract: Tumor-targeted nano-delivery system of therapeutic RNA

Article information

Article type
Review Article
Submitted
05 Dec. 2021
Accepted
25 Janv. 2022
First published
25 Janv. 2022

Mater. Horiz., 2022,9, 1111-1140

Tumor-targeted nano-delivery system of therapeutic RNA

M. Wang, J. Zhao, H. Jiang and X. Wang, Mater. Horiz., 2022, 9, 1111 DOI: 10.1039/D1MH01969D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements