Issue 3, 2022

Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage)

Abstract

Bacterial infection has become a global concern owing to the significant morbidity and mortality. Although the phagocytosis of bacteria by immune cells acts as the front line to protect human body from invading pathogens, the relatively slow encounter and insufficient capture of bacteria by immune cells often lead to an inefficient clearance of pathogens. Herein, a supramolecular artificial receptor-modified macrophage (SAR-Macrophage) was developed to enhance the recognition and latch of bacteria in the systemic circulation, mediated via strong and multipoint host–guest interactions between the artificial receptors (cucurbit[7]uril) on the macrophage and the guest ligands (adamantane) selectively anchored on Escherichia coli (E. coli). As a result, the SAR-Macrophage could significantly accelerate the recognition of E. coli, catch and internalize more pathogens, which subsequently induced the M1 polarization of macrophages to generate ROS and effectively kill the intracellular bacteria. Therefore, the SAR-Macrophage represents a simple, yet powerful anti-bacterial approach.

Graphical abstract: Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage)

Supplementary files

Article information

Article type
Communication
Submitted
10 Nov. 2021
Accepted
22 Dec. 2021
First published
17 Janv. 2022

Mater. Horiz., 2022,9, 934-941

Enhanced antibacterial function of a supramolecular artificial receptor-modified macrophage (SAR-Macrophage)

Q. Cheng, M. Xu, C. Sun, K. Yang, Z. Yang, J. Li, J. Zheng, Y. Zheng and R. Wang, Mater. Horiz., 2022, 9, 934 DOI: 10.1039/D1MH01813B

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