Issue 12, 2022

The era of high-quality chemical probes

Abstract

Small-molecule chemical probes are among the most important tools to study the function of proteins in cells and organisms. Regrettably, the use of weak and non-selective small molecules has generated an abundance of erroneous conclusions in the scientific literature. More recently, minimal criteria have been outlined for investigational compounds, encouraging the selection and use of high-quality chemical probes. Here, we briefly recall the milestones and key initiatives that have paved the way to this new era, illustrate examples of recent high-quality chemical probes and provide our perspective on future challenges and developments.

Graphical abstract: The era of high-quality chemical probes

Article information

Article type
Opinion
Submitted
24 Aug. 2022
Accepted
11 Nov. 2022
First published
28 Nov. 2022
This article is Open Access
Creative Commons BY license

RSC Med. Chem., 2022,13, 1446-1459

The era of high-quality chemical probes

M. P. Licciardello and P. Workman, RSC Med. Chem., 2022, 13, 1446 DOI: 10.1039/D2MD00291D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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