Issue 14, 2022

Paramagnetic ultrasmall Ho2O3 and Tm2O3 nanoparticles: characterization of r2 values and in vivo T2 MR images at a 3.0 T MR field

Abstract

Paramagnetic ultrasmall Ho2O3 and Tm2O3 nanoparticles (davg = ∼2.1 nm) grafted with various hydrophilic and biocompatible ligands such as poly(ethylene glycol) diacid (Mn = 250 and 600 amu) and polyacrylic acid (Mw = 1800 amu) were synthesized via a one-pot polyol method. Appreciable transverse (r2) and negligible longitudinal (r1) water proton spin relaxivity values were observed for all nanoparticle samples. The r2 values increased with increasing nanoparticle magnetic moment and decreased with increasing ligand size. Owing to the aforementioned r1 and r2 values, the nanoparticle samples exhibited appreciable negative contrast enhancements in in vivo T2 magnetic resonance (MR) images at a 3.0 T MR field after intravenous injection, demonstrating their potential as efficient T2 MRI contrast agents.

Graphical abstract: Paramagnetic ultrasmall Ho2O3 and Tm2O3 nanoparticles: characterization of r2 values and in vivo T2 MR images at a 3.0 T MR field

Article information

Article type
Paper
Submitted
21 Marts 2022
Accepted
20 Maijs 2022
First published
23 Maijs 2022
This article is Open Access
Creative Commons BY license

Mater. Adv., 2022,3, 5857-5870

Paramagnetic ultrasmall Ho2O3 and Tm2O3 nanoparticles: characterization of r2 values and in vivo T2 MR images at a 3.0 T MR field

S. Liu, T. Tegafaw, H. Yue, S. L. Ho, S. Kim, J. A. Park, A. Baek, M. Y. Ahmad, S. H. Yang, D. W. Hwang, S. Kim, A. K. Ali Al Saidi, D. Zhao, Y. Liu, S. Nam, K. S. Chae, Y. Chang and G. H. Lee, Mater. Adv., 2022, 3, 5857 DOI: 10.1039/D2MA00322H

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