Issue 19, 2022

Photocatalytic dehydrogenated etherification of 2-aryl benzylic alcohols

Abstract

Here we describe an efficient and practical method for the conversion of 2-aryl benzylic alcohols into the corresponding chromenes through visible-light-induced photoredox catalysis. This protocol has been applied to a wide range of benzylic alcohols, involving pharmaceuticals and natural products, with the synergistic interactions of 2-bromoanthraquinone, O2, nBu4NBr and K2CO3 in EtOH under visible-light irradiation. The late-stage application of this protocol to the synthesis of structurally complex 6H-benzo[c]chromenes proves its synthetic utility.

Graphical abstract: Photocatalytic dehydrogenated etherification of 2-aryl benzylic alcohols

Supplementary files

Article information

Article type
Paper
Submitted
29 Maijs 2022
Accepted
01 Sept. 2022
First published
06 Sept. 2022

Green Chem., 2022,24, 7442-7447

Photocatalytic dehydrogenated etherification of 2-aryl benzylic alcohols

Z. Liang, C. Liu, J. Fan, M. Wang, X. Yan, M. Huang and S. Cai, Green Chem., 2022, 24, 7442 DOI: 10.1039/D2GC02030K

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