Issue 39, 2022

Two-photon absorption-based delivery of nitric oxide from ruthenium nitrosyl complexes

Abstract

Since the discovery of the numerous physiological roles exhibited by nitric oxide (NO), ruthenium nitrosyl (RuNO) complexes have been regarded as one of the most promising NO donors, stable, well tolerated by the body and capable of releasing NO locally and quantitatively, under light irradiation. This release can be achieved by two-photon absorption (TPA) processes, which allow the irradiation to be performed in the near infrared domain, where light has its maximum depth of penetration in biological tissues. This review provides a short introduction on the biological properties of NO, on RuNO complexes with photo-releasing capabilities, and on the origin of TPA properties in molecules. Then, the RuNO complexes with TPA capabilities are thoroughly discussed either as monometallic or polymetallic species.

Graphical abstract: Two-photon absorption-based delivery of nitric oxide from ruthenium nitrosyl complexes

Article information

Article type
Frontier
Submitted
05 Aug. 2022
Accepted
21 Sept. 2022
First published
21 Sept. 2022

Dalton Trans., 2022,51, 14833-14841

Two-photon absorption-based delivery of nitric oxide from ruthenium nitrosyl complexes

P. G. Lacroix, I. Malfant, P. Labra-Vázquez, N. Fárfan and G. Ramos-Ortiz, Dalton Trans., 2022, 51, 14833 DOI: 10.1039/D2DT02553A

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