Issue 4, 2022

Metal-free bioorthogonal click chemistry in cancer theranostics

Abstract

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems. Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and specifically take place in a mild physiological milieu without perturbing inherent biochemical processes. Attributed to their high selectivity and efficiency, bioorthogonal reactions can significantly decrease background signals in bioimaging. Compared with metal-catalyzed bioorthogonal click reactions, metal-free click reactions are more biocompatible without the metal catalyst-induced cytotoxicity. Although a great number of bioorthogonal chemistry-based strategies have been reported for cancer theranostics, a comprehensive review is scarce to highlight the advantages of these strategies. In this review, recent progress in cancer theranostics guided by metal-free bioorthogonal click chemistry will be depicted in detail. The elaborate design as well as the advantages of bioorthogonal chemistry in tumor theranostics are summarized and future prospects in this emerging field are emphasized.

Graphical abstract: Metal-free bioorthogonal click chemistry in cancer theranostics

Article information

Article type
Review Article
Submitted
13 Aug. 2021
First published
20 Janv. 2022

Chem. Soc. Rev., 2022,51, 1336-1376

Metal-free bioorthogonal click chemistry in cancer theranostics

D. Wu, K. Yang, Z. Zhang, Y. Feng, L. Rao, X. Chen and G. Yu, Chem. Soc. Rev., 2022, 51, 1336 DOI: 10.1039/D1CS00451D

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