Issue 35, 2022

Profoundly improved photostability of dimetronidazole by cocrystallization

Abstract

Dimetronidazole (DMZ), an veterinary antibiotic, exhibits poor photostability with only 80.38% potency remaining after exposure to illuminance of 4500 lux for 7 days. The photodegradation is accompanied by obvious color change. A 1 : 1 cocrystal of DMZ with saccharine exhibited profoundly improved photostability with 98.95% of DMZ remaining after 7 days under the same light exposure. Thus, this new cocrystal can be used to develop more stable drug products of DMZ.

Graphical abstract: Profoundly improved photostability of dimetronidazole by cocrystallization

Supplementary files

Article information

Article type
Paper
Submitted
29 Apr. 2022
Accepted
01 Aug. 2022
First published
01 Aug. 2022

CrystEngComm, 2022,24, 6165-6171

Author version available

Profoundly improved photostability of dimetronidazole by cocrystallization

X. Hao, J. Li, C. Wang, X. Zhao, X. He and C. C. Sun, CrystEngComm, 2022, 24, 6165 DOI: 10.1039/D2CE00597B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements