Issue 90, 2022

Catch-enrich-release approach for amine-containing natural products

Abstract

Amine-containing natural products are an important class of therapeutic compounds. Herein, we report a chemoselective approach to catch and enrich amine-containing natural products, and release them as underivatized compounds. The strategy exploits the selectivity of the enzyme legumain for the specific release of amine-containing natural products.

Graphical abstract: Catch-enrich-release approach for amine-containing natural products

Supplementary files

Article information

Article type
Communication
Submitted
05 Sept. 2022
Accepted
14 Okt. 2022
First published
17 Okt. 2022
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2022,58, 12560-12563

Catch-enrich-release approach for amine-containing natural products

M. J. Müller, A. Dorst, C. Paulus, I. Khan and S. Sieber, Chem. Commun., 2022, 58, 12560 DOI: 10.1039/D2CC04905H

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