Issue 96, 2022

Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

Abstract

A crucial reaction in harnessing renewable carbon from lignin is O-demethylation. We demonstrate the selective O-demethylation of syringol and guaiacol using different cytochrome P450 enzymes. These can efficiently use hydrogen peroxide which, when compared to nicotinamide cofactor-dependent monooxygenases and synthetic methods, allows for cheap and clean O-demethylation of lignin-derived aromatics.

Graphical abstract: Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

Supplementary files

Article information

Article type
Communication
Submitted
25 Aug. 2022
Accepted
14 Okt. 2022
First published
08 Nov. 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 13321-13324

Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes

A. C. Harlington, K. E. Shearwin, S. G. Bell and F. Whelan, Chem. Commun., 2022, 58, 13321 DOI: 10.1039/D2CC04698A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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