Issue 78, 2022

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Abstract

Light-activable spatiotemporal control of PROTAC-induced protein degradation was achieved with novel arylazopyrazole photoswitchable PROTACs (AP-PROTACs). The use of a promiscuous kinase inhibitor in the design enables this unique photoswitchable PROTAC to selectively degrade four protein kinases together with on/off optical control using different wavelengths of light.

Graphical abstract: Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Supplementary files

Article information

Article type
Communication
Submitted
01 Jūn. 2022
Accepted
31 Aug. 2022
First published
01 Sept. 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 10933-10936

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Q. Zhang, C. S. Kounde, M. Mondal, J. L. Greenfield, J. R. Baker, S. Kotelnikov, M. Ignatov, C. P. Tinworth, L. Zhang, D. Conole, E. De Vita, D. Kozakov, A. McCluskey, J. D. Harling, M. J. Fuchter and E. W. Tate, Chem. Commun., 2022, 58, 10933 DOI: 10.1039/D2CC03092F

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