Issue 72, 2022

Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

Abstract

Metal–organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).

Graphical abstract: Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

Supplementary files

Article information

Article type
Communication
Submitted
30 Maijs 2022
Accepted
29 Jūl. 2022
First published
01 Aug. 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 10004-10007

Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments

L. Gan, M. D. J. Velásquez-Hernández, A. Emmerstorfer-Augustin, P. Wied, H. Wolinski, S. D. Zilio, M. Solomon, W. Liang, C. Doonan and P. Falcaro, Chem. Commun., 2022, 58, 10004 DOI: 10.1039/D2CC03072A

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