Issue 56, 2022

Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

Abstract

Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.

Graphical abstract: Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

Supplementary files

Article information

Article type
Communication
Submitted
20 Maijs 2022
Accepted
15 Jūn. 2022
First published
22 Jūn. 2022

Chem. Commun., 2022,58, 7769-7772

Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide

J. Gómez-González, L. Martínez-Castro, J. Tolosa-Barrilero, A. Alcalde-Ordóñez, S. Learte-Aymamí, J. L. Mascareñas, J. C. García-Martínez, J. Martínez-Costas, J. Maréchal, M. Vázquez López and M. E. Vázquez, Chem. Commun., 2022, 58, 7769 DOI: 10.1039/D2CC02874C

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