Issue 6, 2022

Palladium-catalyzed oxidative C–H/C–H cross-coupling of pyrazolo[1,5-a]azines with five-membered heteroarenes

Abstract

The use of Pd(OAc)2 as the catalyst and AgOAc as the oxidant enabled the direct regioselective oxidative C–H/C–H cross-coupling of pyrazolo[1,5-a]pyrimidines or pyrazolo[1,5-a]pyridines with various five-membered heteroarenes without the need of pre-activation and/or directing groups. Successful coupling partners include thiophenes, benzothiophenes, thiazoles, furans, oxazoles, indoles and imidazo[1,2-a]pyridines.

Graphical abstract: Palladium-catalyzed oxidative C–H/C–H cross-coupling of pyrazolo[1,5-a]azines with five-membered heteroarenes

Supplementary files

Article information

Article type
Communication
Submitted
10 Nov. 2021
Accepted
15 Dec. 2021
First published
15 Dec. 2021

Chem. Commun., 2022,58, 827-830

Palladium-catalyzed oxidative C–H/C–H cross-coupling of pyrazolo[1,5-a]azines with five-membered heteroarenes

T. V. Q. Nguyen, L. Poli and A. T. Garrison, Chem. Commun., 2022, 58, 827 DOI: 10.1039/D1CC06337E

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