Issue 8, 2022

Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones

Abstract

A novel tactic for the regioselective O-alkylation of 2-pyridones has been realized through palladium catalysis in moderate to high yields. The coordination effect between palladium and nitrogen on the pyridine ring plays a versatile role.

Graphical abstract: Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones

Supplementary files

Article information

Article type
Communication
Submitted
01 Nov. 2021
Accepted
17 Dec. 2021
First published
20 Dec. 2021

Chem. Commun., 2022,58, 1215-1218

Coordination effect enabled palladium-catalyzed regioselective O-alkylation of 2-pyridones

Z. Lu, Y. Li, Y. Ru, S. Yang, C. Hao, M. Zuo, R. Jiao, W. Wu, Y. Zhou, H. Yao, N. Huang and Y. Fu, Chem. Commun., 2022, 58, 1215 DOI: 10.1039/D1CC06110K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements