Issue 1, 2022

ROS activated prodrug for ALDH overexpressed cancer stem cells

Abstract

Aldehyde dehydrogenase (ALDH), a cancer stem cell biomarker, is related to drug resistance. Co-treatment of anti-cancer drug (CPT) and ALDH inhibitor (DEAB) can overcome the drug resistance of cancer stem cells (CSCs) and finally cure cancers without relapse. We herein introduce a prodrug (DE-CPT) – consisting of 1,3-oxathiolane as an ROS responsive scaffold, and an aldehyde protecting group of DEAB – to deliver the CPT and DEAB upon reaction with ROS. From tests of the sphere-forming ability and CSC marker subpopulation, we found that DE-CPT efficiently decreases the CSCs population and kills the cancer cells.

Graphical abstract: ROS activated prodrug for ALDH overexpressed cancer stem cells

Supplementary files

Article information

Article type
Communication
Submitted
08 Okt. 2021
Accepted
25 Nov. 2021
First published
07 Dec. 2021

Chem. Commun., 2022,58, 72-75

ROS activated prodrug for ALDH overexpressed cancer stem cells

M. Won, J. H. Kim, M. S. Ji and J. S. Kim, Chem. Commun., 2022, 58, 72 DOI: 10.1039/D1CC05573A

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