Issue 2, 2022

A mitochondrial and lysosomal targeted ratiometric probe for detecting intracellular H2S

Abstract

Based on coumarin and benzopyran derivatives, a dual-wavelength excitation ratiometric fluorescent probe, HABA, was prepared to detect H2S. The HABA probe showed good selectivity and anti-interference abilities during H2S detection. Fluorescence co-localization experiments showed that HABA had excellent localization abilities toward mitochondria and lysosomes. More importantly, HABA can not only detect exogenous H2S, but it can also detect endogenous H2S, indicating that HABA has high application potential and value in the biological field.

Graphical abstract: A mitochondrial and lysosomal targeted ratiometric probe for detecting intracellular H2S

Supplementary files

Article information

Article type
Paper
Submitted
19 Okt. 2021
Accepted
13 Dec. 2021
First published
13 Dec. 2021

Anal. Methods, 2022,14, 101-105

A mitochondrial and lysosomal targeted ratiometric probe for detecting intracellular H2S

W. Liu, D. Bu, H. Zhang, M. Zhang, H. Ren, Z. Li and M. Yu, Anal. Methods, 2022, 14, 101 DOI: 10.1039/D1AY01783G

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