Issue 40, 2021

Highly sensitive non-enzymatic electrochemical glucose sensor surpassing water oxidation interference

Abstract

An electrochemical non-enzymatic sensor based on a NiVP/Pi material was developed for the selective and sensitive determination of glucose. The novel sensor showed a high sensitivity of 6.04 mA μM−1 cm−2 with a lowest detection limit of 3.7 nM in a wide detection range of 100 nM–10 mM. The proposed sensor exhibited a superior selectivity without any interference from the oxygen evolution reaction during glucose sensing. We also found that this glucose sensor showed negligible interference from various interferents, such as ascorbic acid, uric acid, dopamine and sodium chloride. Additionally, a novel flexible sensor was developed by coating the NiVP/Pi over Whatman filter paper, which exhibited two linear ranges of 100 nM to 1 μM and 100 μM to 10 mM with an ultra-sensitivity of 1.130 mA μM−1 cm−2 and 0.746 mA μM−1 cm−2, respectively, in 0.1 M NaOH. The proposed sensor was tested with human blood serum samples demonstrating its practical application. Our findings provide a new route by fine tuning the composition of nickel and vanadium that sheds new light on better understanding the processes. This NiVP/Pi-based sensor offers a new approach towards the electrochemical detection of glucose, enabling glucose monitoring in a convenient way.

Graphical abstract: Highly sensitive non-enzymatic electrochemical glucose sensor surpassing water oxidation interference

Supplementary files

Article information

Article type
Paper
Submitted
14 Jūn. 2021
Accepted
12 Jūl. 2021
First published
14 Jūl. 2021

J. Mater. Chem. B, 2021,9, 8399-8405

Highly sensitive non-enzymatic electrochemical glucose sensor surpassing water oxidation interference

N. Thakur, D. Mandal and T. C. Nagaiah, J. Mater. Chem. B, 2021, 9, 8399 DOI: 10.1039/D1TB01332G

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