Issue 34, 2021

Advances and impact of arginine-based materials in wound healing

Abstract

In studies on wound-dressing materials, bioactive materials have been developed rapidly to accelerate wound healing. In recent years, scientists have studied arginine as a bioactive component due to its excellent biosafety, antimicrobial properties and therapeutic effects on wound healing. Surprisingly, arginine therapy is also used under specific pathological conditions, such as diabetes and trauma/hemorrhagic shock. Due to the broad utilization of arginine-assisted therapy, we present the unique properties of arginine for healing lesions of damaged tissue and examined multiple arginine-based systems for the application of wound healing. This review shows that arginine-based therapy can be separated in two categories: direct supplemental approaches of free arginine, and indirect approaches based on arginine derivatives in which modified arginine can be released after biodegradation. Using these two pathways, arginine-based therapy may prove to be a promising strategy in the development of wound curative treatments.

Graphical abstract: Advances and impact of arginine-based materials in wound healing

Article information

Article type
Review Article
Submitted
28 Apr. 2021
Accepted
05 Jūl. 2021
First published
14 Jūl. 2021

J. Mater. Chem. B, 2021,9, 6738-6750

Advances and impact of arginine-based materials in wound healing

Y. Zhou, G. Liu, H. Huang and J. Wu, J. Mater. Chem. B, 2021, 9, 6738 DOI: 10.1039/D1TB00958C

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