Issue 60, 2021

Recent applications of solid-phase strategy in total synthesis of antibiotics

Abstract

Antibiotics produced by soil microorganisms have been widespread and have cured the most prevalent diseases since 1940s. However, recent bacterial resistance to existing antibacterial drugs is causing a public health crisis. The structure–activity relationship of antibiotics needs to be established to search for existing antibiotics-based next-generation drug candidates that can conquer the challenge of bacterial resistance preparedness, which relies on the development of highly efficient total synthesis strategies. The solid-phase strategy has become important to circumvent tedious intermediate isolation and purification procedures with simple filtrations. This review will give a brief overview of recent applications of solid-phase strategy in the total synthesis of antibiotics.

Graphical abstract: Recent applications of solid-phase strategy in total synthesis of antibiotics

Article information

Article type
Review Article
Submitted
10 Okt. 2021
Accepted
11 Nov. 2021
First published
24 Nov. 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 37942-37951

Recent applications of solid-phase strategy in total synthesis of antibiotics

Y. Zhou and X. Liang, RSC Adv., 2021, 11, 37942 DOI: 10.1039/D1RA07503A

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