Issue 60, 2021

Recent advances of N-heterocyclic carbenes in the applications of constructing carbo- and heterocyclic frameworks with potential biological activity

Abstract

In recent years, N-heterocyclic carbenes (NHCs) have established themselves as a masterful and promising type of organocatalyst for the speedy construction of medicinally and biologically significant molecules from common and accessible small molecules. In particular, various cyclic scaffolds, including carbocycles and heterocycles, have been synthesized using NHCs via cycloaddition reaction. An exhaustive review focused on the chemistry of NHCs in these cyclic molecules has yet to be reported. In this contribution, a general picture of the utilization of NHCs in constructing twelve kinds of bioactive cyclic skeletons is firstly presented. We provide a systematic and comprehensive overview from the perspective of cycloaddition reactions; moreover, the limitations, challenges, and future prospects were discussed.

Graphical abstract: Recent advances of N-heterocyclic carbenes in the applications of constructing carbo- and heterocyclic frameworks with potential biological activity

Article information

Article type
Review Article
Submitted
14 Aug. 2021
Accepted
05 Nov. 2021
First published
26 Nov. 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 38060-38078

Recent advances of N-heterocyclic carbenes in the applications of constructing carbo- and heterocyclic frameworks with potential biological activity

M. Li, X. Chen, Y. Deng and J. Lu, RSC Adv., 2021, 11, 38060 DOI: 10.1039/D1RA06155K

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