Issue 53, 2021

Direct halosulfonylation of alkynes: an overview

Abstract

The difunctionalization reactions of easily available and inexpensive alkynes have emerged as a reliable, powerful, and step-economical approach for the construction of highly substituted complex alkenes in a one-pot manner, without the need for isolation of intermediates. A wide variety of transformations based on this concept have been successfully achieved for the preparation of synthetically and biologically important β-halovinyl sulfone scaffolds. In this Review, we summarize the recent advances and developments in this field and present a comprehensive overview of halosulfonylation of alkyne substrates with emphasis on the mechanistic features of the reactions.

Graphical abstract: Direct halosulfonylation of alkynes: an overview

Article information

Article type
Review Article
Submitted
02 Maijs 2021
Accepted
30 Sept. 2021
First published
13 Okt. 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 33447-33460

Direct halosulfonylation of alkynes: an overview

Y. Zhang and E. Vessally, RSC Adv., 2021, 11, 33447 DOI: 10.1039/D1RA03443J

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