Issue 15, 2021

Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles

Abstract

Asymmetric catalytic multicomponent cascade reactions have become indispensable tools for enantioselective construction of spirooxindoles. In recent years, a number of successful strategies have been developed for the synthesis of enantioenriched spirooxindoles in high yield with excellent stereo- and regioselectivity. This review summarizes the recent advances on enantioselective construction of spirooxindoles including spiro[N-heterocycle-oxindoles], spiro[cycloalkane-oxindoles] and spiro[O-heterocycle-oxindoles] catalyzed by chiral phosphoric acids, amines, and bifunctional thiourea/squaramides.

Graphical abstract: Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles

Article information

Article type
Review Article
Submitted
07 Febr. 2021
Accepted
02 Maijs 2021
First published
07 Maijs 2021

Org. Chem. Front., 2021,8, 4315-4348

Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles

Y. Wang, A. A. Cobo and A. K. Franz, Org. Chem. Front., 2021, 8, 4315 DOI: 10.1039/D1QO00220A

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