Issue 11, 2021

Symmetric cytotoxic trimeric and dimeric indole alkaloids isolated from Bousigonia angustifolia

Abstract

A symmetric monoterpenoid indole alkaloid trimer, bousangustine A, is reported for the first time, as well as the dimeric alkaloids bousangustines B and C; these were isolated from the trunks of Bousigonia angustifolia. The structures, which feature a symmetric 6/9/5/6 ring system, were elucidated using comprehensive spectroscopic analysis. Their absolute configurations were determined via X-ray crystal diffraction, as well as computational chemistry. They can be constructed through Friedel–Crafts and free radical reactions, respectively. These compounds exhibited significant cytotoxicity against tumor cells.

Graphical abstract: Symmetric cytotoxic trimeric and dimeric indole alkaloids isolated from Bousigonia angustifolia

Supplementary files

Article information

Article type
Research Article
Submitted
14 Dec. 2020
Accepted
08 Febr. 2021
First published
16 Marts 2021

Org. Chem. Front., 2021,8, 2601-2607

Symmetric cytotoxic trimeric and dimeric indole alkaloids isolated from Bousigonia angustifolia

B. Shi, J. Lu, J. Wu, M. Bao and X. Cai, Org. Chem. Front., 2021, 8, 2601 DOI: 10.1039/D0QO01565B

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