Issue 13, 2021

Strategies and methodologies for the construction of spiro-γ-lactams: an update

Abstract

Spiro-γ-lactams (spiropyrrolidin-2-ones) are a class of spirocyclic compounds that are present in a wide range of synthetic bioactive and naturally occurring molecules. The increasing attention to spirocyclic lactams in drug discovery has been accompanied by a growing interest in these compounds from a synthetic point of view, namely as synthetic building blocks in organic chemistry, due to their inherent rigidity and complexity. Herein, an insight into the most relevant advances in the synthesis of the spiro-γ-lactam scaffold since 2015 is provided, addressing issues such as scope, efficiency, selectivity and mechanistic insights.

Graphical abstract: Strategies and methodologies for the construction of spiro-γ-lactams: an update

Article information

Article type
Review Article
Submitted
11 Dec. 2020
Accepted
18 Apr. 2021
First published
19 Apr. 2021

Org. Chem. Front., 2021,8, 3543-3593

Strategies and methodologies for the construction of spiro-γ-lactams: an update

A. J. S. Alves, N. G. Alves, M. I. L. Soares and T. M. V. D. Pinho e Melo, Org. Chem. Front., 2021, 8, 3543 DOI: 10.1039/D0QO01564D

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