Issue 20, 2021

Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

Abstract

By virtue of their rich photophysical and photochemical properties, transition metal complexes (TMCs) have been extensively studied in multidisciplinary research. In this review, recent studies on TMCs for biological applications are described with a focus on the behaviour of TMCs as specific intracellular sensors and organelle-targeting imaging reagents. Some prominent examples of TMCs as photosensitisers for in vitro and in vivo phototherapies, such as photodynamic therapy and photoactivated chemotherapy, are highlighted. Also, future development of TMCs for new diagnostic and therapeutic applications is discussed.

Graphical abstract: Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

Supplementary files

Article information

Article type
Review Article
Submitted
26 Jūl. 2021
Accepted
01 Sept. 2021
First published
03 Sept. 2021

Inorg. Chem. Front., 2021,8, 4553-4579

Photofunctional transition metal complexes as cellular probes, bioimaging reagents and phototherapeutics

G. Xu, E. C. Mak and K. K. Lo, Inorg. Chem. Front., 2021, 8, 4553 DOI: 10.1039/D1QI00931A

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