Issue 45, 2021

Automated glycan assembly of peptidoglycan backbone fragments

Abstract

We report the automated glycan assembly (AGA) of different oligosaccharide fragments of the bacterial peptidoglycan (PGN) backbone. Iterative addition on a solid support of an acetyl glucosamine and a new muramic acid building block is followed by cleavage from the solid support and final deprotection providing 10 oligosaccharides up to six units.

Graphical abstract: Automated glycan assembly of peptidoglycan backbone fragments

Supplementary files

Article information

Article type
Communication
Submitted
10 Okt. 2021
Accepted
22 Okt. 2021
First published
25 Okt. 2021
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2021,19, 9829-9832

Automated glycan assembly of peptidoglycan backbone fragments

P. Dallabernardina, V. Benazzi, J. D. Laman, P. H. Seeberger and F. F. Loeffler, Org. Biomol. Chem., 2021, 19, 9829 DOI: 10.1039/D1OB01987B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements