Issue 44, 2021
From the journal:

Organic & Biomolecular Chemistry

Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams†

Yi Zheng,‡a   Ting-Ting Zhang‡a  and  Wen-Bo Shen ORCID logo *a  

* Corresponding authors

a College of Sciences, Henan Agricultural University, Zhengzhou 450002, China
E-mail: wenboshen@henau.edu.cn

Abstract

An efficient gold-catalyzed oxidative cyclization of amide-alkynes is developed. A series of functionalized γ-lactams are easily accessed by employing this strategy. The tandem reaction proceeds through alkyne oxidation, carbene/alkyne metathesis, and donor/donor carbene oxidation.

Graphical abstract: Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D1OB01846A
Article type
Paper
Submitted
17 Sept. 2021
Accepted
22 Okt. 2021
First published
22 Okt. 2021

Org. Biomol. Chem., 2021,19, 9688-9691

Permissions

Request permissions

Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams

Y. Zheng, T. Zhang and W. Shen, Org. Biomol. Chem., 2021, 19, 9688 DOI: 10.1039/D1OB01846A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements