Issue 29, 2021

Chalcogen bonding mediates the formation of supramolecular helices of azapeptides in crystals

Abstract

To explore whether chalcogen bonding was able to drive the formation of supramolecular helices, alanine-based azapeptides containing a β-turn structure, with a thiophene group, respectively, incorporated in the N- or C-terminus, were employed as helical building blocks. While the former derivative formed a supramolecular M-helix via intermolecular S⋯S chalcogen bonding in crystals, the latter formed P-helix via intermolecular S⋯O chalcogen bonding.

Graphical abstract: Chalcogen bonding mediates the formation of supramolecular helices of azapeptides in crystals

Supplementary files

Article information

Article type
Communication
Submitted
31 Maijs 2021
Accepted
05 Jūl. 2021
First published
05 Jūl. 2021

Org. Biomol. Chem., 2021,19, 6397-6401

Chalcogen bonding mediates the formation of supramolecular helices of azapeptides in crystals

D. Shi, J. Cao, P. Weng, X. Yan, Z. Li and Y. Jiang, Org. Biomol. Chem., 2021, 19, 6397 DOI: 10.1039/D1OB01053K

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