Issue 1, 2021

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Abstract

A mild, chemoselective and sustainable biocatalysed synthesis of sulfoxides has been developed exploiting CALB and using AcOEt with a dual role of more environmentally friendly reaction solvent and enzyme substrate. A series of sulfoxides, including the drug omeprazole, have been synthesised in high yields and with excellent E-factors.

Graphical abstract: A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

Supplementary files

Article information

Article type
Communication
Submitted
24 Sept. 2020
Accepted
05 Nov. 2020
First published
06 Nov. 2020

Org. Biomol. Chem., 2021,19, 156-161

A mild and chemoselective CALB biocatalysed synthesis of sulfoxides exploiting the dual role of AcOEt as solvent and reagent

S. Anselmi, S. Liu, S. Kim, S. M. Barry, T. S. Moody and D. Castagnolo, Org. Biomol. Chem., 2021, 19, 156 DOI: 10.1039/D0OB01966F

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