Issue 35, 2021

Enhanced drug retention by anthracene crosslinked nanocomposites for bimodal imaging-guided phototherapy

Abstract

Efficient drug delivery, multifunctional combined therapy and real-time diagnosis are the main hallmarks in the exploitation of precision nanomedicine. Herein, an anthracene-functionalized micelle containing a magnetic resonance imaging (MRI) contrast agent, upconversion nanoparticles (UCNPs) and the photosensitizer IR780 is designed to achieve sustained drug release and enhanced photothermal and photodynamic therapy. The polymer-coated hybrid micelle was achieved by crosslinking anthracene-dimer with UV light (λ > 300 nm), which is converted from near-infrared (NIR) irradiation upon UCNPs. Besides, the water-insoluble photosensitizer IR780 is introduced into the system to achieve efficient drug delivery and photothermal and photodynamic synergistic therapy. As a consequence of NIR-induced anthracene-dimer formation, the cross-linked nanocomposite shows sustained drug release, and the enhanced retention effect of IR780 could increase the photothermal conversion efficiency. Importantly, the incorporation of 2,2,6,6-tetramethyl-piperidineoxyl (TEMPO) as a nitroxide MRI contrast agent presents the potential for real-time diagnosis via nanotheranostics, and the fluorescence imaging of IR780 is applied to monitor drug distribution and metabolism. This strategy of sustained drug delivery by anthracene-dimer formation through the better penetration depth of NIR-II fluorescence provides an executable platform to achieve enhanced phototherapy in biomedical applications.

Graphical abstract: Enhanced drug retention by anthracene crosslinked nanocomposites for bimodal imaging-guided phototherapy

Supplementary files

Article information

Article type
Paper
Submitted
28 Jūn. 2021
Accepted
12 Aug. 2021
First published
16 Aug. 2021

Nanoscale, 2021,13, 14713-14722

Enhanced drug retention by anthracene crosslinked nanocomposites for bimodal imaging-guided phototherapy

X. Fan, L. Ke, H. Cheng, H. Chen, Z. Li, E. Ye, X. Loh, Y. Wu, G. Liu and Z. Li, Nanoscale, 2021, 13, 14713 DOI: 10.1039/D1NR04171A

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