Issue 15, 2021

Recent progress in mitochondria-targeting-based nanotechnology for cancer treatment

Abstract

Mitochondria play critical roles in the regulation of the proliferation and apoptosis of cancerous cells. Nanosystems for targeted delivery of cargos to mitochondria for cancer treatment have attracted increasing attention in the past few years. This review will summarize the state of the art of design and construction of nanosystems used for mitochondria-targeted delivery. The use of nanotechnology for cancer treatment through various pathways such as energy metabolism interference, reactive oxygen species (ROS) regulation, mitochondrial protein targeting, mitochondrial DNA (mtDNA) interference, mitophagy inducing, and combination therapy will be discussed. Finally, the major challenges and an outlook in this field will also be provided.

Graphical abstract: Recent progress in mitochondria-targeting-based nanotechnology for cancer treatment

Article information

Article type
Minireview
Submitted
17 Febr. 2021
Accepted
03 Apr. 2021
First published
03 Apr. 2021

Nanoscale, 2021,13, 7108-7118

Recent progress in mitochondria-targeting-based nanotechnology for cancer treatment

J. Qin, N. Gong, Z. Liao, S. Zhang, P. Timashev, S. Huo and X. Liang, Nanoscale, 2021, 13, 7108 DOI: 10.1039/D1NR01068A

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