Issue 40, 2021

Transition metal-free C-3 functionalization of quinoxalin-2(1H)-ones: recent advances and sanguine future

Abstract

Transition metal-free C-3 functionalization of quinoxalin-2(1H)-ones has recently emerged as a modern sustainable protocol, as C-3 functionalized quinoxalin-2(1H)-ones offer robust applications in the medicinal, pharmaceutical and agriculture industry. In recent times, various sustainable protocols for the construction of C–C, C–N, C–P, C–S, and C–O bonds via the C–H functionalization of quinoxalin-2(1H)-ones were developed. A gradual shift from metal-catalyzed to metal-free methodologies has been observed in last few years, as the latter provide an environmentally benign synthetic route in organic chemistry. The present review offers an extensive discussion on recent advances in transition metal-free C–H functionalization of quinoxalin-2(1H)-ones. The review has been decoratively categorized based on C–C, C–O/C–S and C–N/C–P bond formation using metal-free, visible light and electrochemically catalyzed strategies. In addition, mechanistic features of chemical transformation of quinoxalin-2(1H)-ones have been highlighted.

Graphical abstract: Transition metal-free C-3 functionalization of quinoxalin-2(1H)-ones: recent advances and sanguine future

Article information

Article type
Perspective
Submitted
16 Jūl. 2021
Accepted
03 Sept. 2021
First published
04 Sept. 2021

New J. Chem., 2021,45, 18722-18763

Transition metal-free C-3 functionalization of quinoxalin-2(1H)-ones: recent advances and sanguine future

Kiran, P. Rani, S. Chahal, J. Sindhu, S. Kumar, R. S. Varma and R. Singh, New J. Chem., 2021, 45, 18722 DOI: 10.1039/D1NJ03445F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements