Issue 5, 2021

Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

Abstract

A living therapeutic system based on attenuated Salmonella was developed via metabolic engineering using an aggregation-induced emission (AIE) photosensitizer MA. The engineered bacteria could localize in the tumor tissues and continue to colonize and express exogenous genes. Under light irradiation, the encoded VEGFR2 gene was released and expressed in tumor tissues, which can suppress angiogenesis induced by a T cell-mediated autoimmune response and inhibit tumor growth.

Graphical abstract: Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

Supplementary files

Article information

Article type
Communication
Submitted
04 Okt. 2020
Accepted
15 Dec. 2020
First published
16 Dec. 2020

Mater. Horiz., 2021,8, 1454-1460

Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy

X. Liu, M. Wu, M. Wang, Y. Duan, C. Phan, G. Qi, G. Tang and B. Liu, Mater. Horiz., 2021, 8, 1454 DOI: 10.1039/D0MH01582B

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