Issue 12, 2021

Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN

Abstract

In their role as pattern-recognition receptors on cells of the innate immune system, myeloid C-type lectin receptors (CLRs) assume important biological functions related to immunity, homeostasis, and cancer. As such, this family of receptors represents an appealing target for therapeutic interventions for modulating the outcome of many pathological processes, in particular related to infectious diseases. This review summarizes the current state of research into glycomimetic or drug-like small molecule ligands for the CLRs Mincle, Langerin, and DC-SIGN, which have potential therapeutic applications in vaccine research and anti-infective therapy.

Graphical abstract: Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN

Article information

Article type
Review Article
Submitted
15 Jūl. 2021
Accepted
14 Sept. 2021
First published
16 Sept. 2021
This article is Open Access
Creative Commons BY-NC license

RSC Med. Chem., 2021,12, 1985-2000

Medicinal chemistry of the myeloid C-type lectin receptors Mincle, Langerin, and DC-SIGN

J. Cramer, RSC Med. Chem., 2021, 12, 1985 DOI: 10.1039/D1MD00238D

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