Issue 11, 2021

Polarity-based fluorescence probes: properties and applications

Abstract

Local polarity can affect the physical or chemical behaviors of surrounding molecules, especially in organisms. Cell polarity is the ultimate feedback of cellular status and regulation mechanisms. Hence, the abnormal alteration of polarity in organisms is closely linked with functional disorders and many diseases. It is incredibly significant to monitor and detect local polarity to explain the biological processes and diagnoses of some diseases. Because of their in vivo safe and real-time monitoring, several polarity-sensitive fluorophores and fluorescent probes have gradually emerged and been used in modern research. This review summarizes the fluorescence properties and applications of several representative polarity-sensitive fluorescent probes.

Graphical abstract: Polarity-based fluorescence probes: properties and applications

Article information

Article type
Review Article
Submitted
17 Maijs 2021
Accepted
07 Aug. 2021
First published
09 Aug. 2021

RSC Med. Chem., 2021,12, 1826-1838

Polarity-based fluorescence probes: properties and applications

X. Qin, X. Yang, L. Du and M. Li, RSC Med. Chem., 2021, 12, 1826 DOI: 10.1039/D1MD00170A

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