Issue 4, 2021

The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria

Abstract

Tridecaptins are a re-emerging class of non-ribosomal antibacterial peptides (NRAPs) with potent activity against highly problematic strains of Gram-negative bacteria. An intricate mode of action has been reported to explain the bactericidal activity of these NRAPs, wherein they bind selectivity to the Gram-negative version of the peptidoglycan precursor lipid II on the outer leaflet of the inner membrane and disrupt the proton-motive force. Tridecaptins are highly amenable to synthetic modification owing to their linear structure, therefore, various synthetic analogues have been reported, several of which have enhanced antimicrobial activity, reduced cost of synthesis and/or improved stability towards D-peptidase mediated hydrolysis. It has also been demonstrated that unacylated tridecaptins can act synergistically with clinically relevant antibiotics by sensitizing the outer membrane. This review will summarize past literature on the development/discovery of novel tridecaptin analogues (up until the end of 2020), some of which may be useful therapeutic agents to treat insidious Gram-negative bacterial infections.

Graphical abstract: The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria

Supplementary files

Article information

Article type
Review Article
Submitted
07 Dec. 2020
Accepted
12 Janv. 2021
First published
22 Janv. 2021
This article is Open Access
Creative Commons BY license

RSC Med. Chem., 2021,12, 538-551

The tridecaptins: non-ribosomal peptides that selectively target Gram-negative bacteria

S. J. Bann, R. D. Ballantine and S. A. Cochrane, RSC Med. Chem., 2021, 12, 538 DOI: 10.1039/D0MD00413H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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