Issue 2, 2021

Application of ICP-MS to the development of metal-based drugs and diagnostic agents: where do we stand?

Abstract

Metallodrug development presents one of the ‘killer’ applications to sustain further progress of ICP-MS which even with its hyphenated, metallomics-directed configurations has long since attained the status of a mature analytical technique. The incremental advance of ICP-MS in the field is codified and critically assessed in this review. Providing thus an update of a previous review article by the author (see A. R. Timerbaev, J. Anal. At. Spectrom., 2014, 29, 1058–1072), it covers the topics of monitoring the drug–biomolecule interactions, studying cellular and tissue distribution, probing the intracellular transformation and profiling active metabolites, all of which benefit from the sensitive and precise determination of drug-comprising metals. Special emphasis is placed on ICP-MS-based methodologies that offer new insights into drug activation and targeting chemistries. Also addressed are demanding issues of ascertaining the cellular response to a drug and performing tissue imaging in a high-resolution and quantitative way.

Graphical abstract: Application of ICP-MS to the development of metal-based drugs and diagnostic agents: where do we stand?

Article information

Article type
Critical Review
Submitted
13 Sept. 2020
Accepted
14 Janv. 2021
First published
14 Janv. 2021

J. Anal. At. Spectrom., 2021,36, 254-266

Application of ICP-MS to the development of metal-based drugs and diagnostic agents: where do we stand?

A. R. Timerbaev, J. Anal. At. Spectrom., 2021, 36, 254 DOI: 10.1039/D0JA00404A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements