Issue 10, 2021

Can determination of extractable organofluorine (EOF) be standardized? First interlaboratory comparisons of EOF and fluorine mass balance in sludge and water matrices

Abstract

The high proportion of unidentified extractable organofluorine (EOF) observed globally in humans and the environment indicates widespread occurrence of unknown per- and polyfluoroalkyl substances (PFAS). However, efforts to standardize or assess the reproducibility of EOF methods are currently lacking. Here we present the first EOF interlaboratory comparison in water and sludge. Three participants (four organizations) analyzed unfortified and PFAS-fortified ultrapure water, two unfortified groundwater samples, unfortified wastewater treatment plant effluent and sludge, and an unfortified groundwater extract. Participants adopted common sample handling strategies and target lists for EOF mass balance but used in-house combustion ion-chromatography (CIC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods. EOF accuracy ranged from 85–101% and 76–109% for the 60 and 334 ng L−1 fluorine (F) – fortified water samples, respectively, with between-laboratory variation of 9–19%, and within-laboratory variation of 3–27%. In unfortified sludge and aqueous samples, between-laboratory variation ranged from 21–37%. The contribution from sum concentrations of 16 individual PFAS (∑PFAS-16) to EOF ranged from 2.2–60% but extended analysis showed that other targets were prevalent, in particular ultra-short-chain perfluoroalkyl acids (e.g. trifluoroacetic acid) in aqueous samples and perfluoroalkyl acid-precursors (e.g. polyfluoroalkyl phosphate diesters) in sludge. The EOF-CIC method demonstrated promising accuracy, robustness and reporting limits but poor extraction efficiency was observed for some targets (e.g. trifluoroacetic acid).

Graphical abstract: Can determination of extractable organofluorine (EOF) be standardized? First interlaboratory comparisons of EOF and fluorine mass balance in sludge and water matrices

Supplementary files

Article information

Article type
Communication
Submitted
08 Jūn. 2021
Accepted
08 Sept. 2021
First published
10 Sept. 2021
This article is Open Access
Creative Commons BY-NC license

Environ. Sci.: Processes Impacts, 2021,23, 1458-1465

Can determination of extractable organofluorine (EOF) be standardized? First interlaboratory comparisons of EOF and fluorine mass balance in sludge and water matrices

A. Kärrman, L. W. Y. Yeung, K. M. Spaan, F. T. Lange, M. A. Nguyen, M. Plassmann, C. A. de Wit, M. Scheurer, R. Awad and J. P. Benskin, Environ. Sci.: Processes Impacts, 2021, 23, 1458 DOI: 10.1039/D1EM00224D

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