Issue 46, 2021

Polymorph control of 5-fluorouracil during a ball milling process

Abstract

Polymorph control of 5-fluorouracil (5-FU) was achieved by ball milling. Form II was synthesized through one-step neat grinding of raw 5-FU (RFU), and Form III (a new polymorph) was obtained by neat grinding RFU twice. Forms II and III of 5-FU were prepared separately through ball milling with different amounts of ethanol as an additive at the same period without influencing each other.

Graphical abstract: Polymorph control of 5-fluorouracil during a ball milling process

Supplementary files

Article information

Article type
Communication
Submitted
07 Sept. 2021
Accepted
28 Okt. 2021
First published
28 Okt. 2021

CrystEngComm, 2021,23, 8027-8032

Polymorph control of 5-fluorouracil during a ball milling process

F. Chen, J. Fan, X. Chen, Y. Li, C. Liang, S. Ren and R. Xue, CrystEngComm, 2021, 23, 8027 DOI: 10.1039/D1CE01211H

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