Issue 22, 2021

Selective formation of form II paracetamol through the assistance of paracetamol co-crystals as templates in a solution

Abstract

Selective formation for form II instead of form I paracetamol was promoted through the assistance of structurally related packing motifs and arrangements of paracetamol co-crystals in an aqueous solution. Form II paracetamol was produced by cooling crystallization in water with either oxalic acid or maleic acid. The co-crystal lattice structures of paracetamol with oxalic acid and maleic acid were similar to the packing pattern of form II paracetamol.

Graphical abstract: Selective formation of form II paracetamol through the assistance of paracetamol co-crystals as templates in a solution

Supplementary files

Article information

Article type
Communication
Submitted
08 Janv. 2021
Accepted
26 Apr. 2021
First published
28 Apr. 2021

CrystEngComm, 2021,23, 3940-3945

Selective formation of form II paracetamol through the assistance of paracetamol co-crystals as templates in a solution

K. L. Yeh and T. Lee, CrystEngComm, 2021, 23, 3940 DOI: 10.1039/D1CE00034A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements