Issue 93, 2021

Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2

Abstract

We identified small-molecule enhancers of cellular stress granules by observing molecular crowding of proteins and RNAs in a time-dependent manner. Hit molecules sensitized the IRF3-mediated antiviral mechanism in the presence of poly(I:C) and inhibited the replication of SARS-CoV-2 by inducing stress granule formation. Thus, modulating multimolecular crowding can be a promising strategy against SARS-CoV-2.

Graphical abstract: Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2

Supplementary files

Article information

Article type
Communication
Submitted
30 Sept. 2021
Accepted
22 Okt. 2021
First published
26 Okt. 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2021,57, 12476-12479

Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2

W. G. Byun, J. Lee, S. Kim and S. B. Park, Chem. Commun., 2021, 57, 12476 DOI: 10.1039/D1CC05508A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements