Issue 90, 2021

Transition metal catalyzed C–H bond activation by exo-metallacycle intermediates

Abstract

exo-Metallacycles have become the key reaction intermediates in activating various remote C(sp2)–H and C(sp3)–H bonds in the past decade and aided in achieving unusual site-selectivity. Various novel exo-chelating auxiliaries have assisted metals to reach desired remote C–H bonds of different alcohol and amine-derived substrates. As a result, a wide range of organic transformations of C–H bonds like halogenation, acetoxylation, amidation, sulfonylation, olefination, acylation, arylation, etc. were accessible using the exo-metallacycle strategy. In this review, we have summarized the developments in C–H bond activation via four-, five-, six-, seven- and eight-membered exo-metallacycles and the key reaction intermediates, including the mechanistic aspects, are discussed concisely.

Graphical abstract: Transition metal catalyzed C–H bond activation by exo-metallacycle intermediates

Article information

Article type
Feature Article
Submitted
07 Sept. 2021
Accepted
29 Sept. 2021
First published
29 Sept. 2021

Chem. Commun., 2021,57, 11885-11903

Transition metal catalyzed C–H bond activation by exo-metallacycle intermediates

S. R. Sahoo, S. Dutta, S. A. Al-Thabaiti, M. Mokhtar and D. Maiti, Chem. Commun., 2021, 57, 11885 DOI: 10.1039/D1CC05042G

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