Issue 99, 2021

Supramolecular capture of highly polar amidosquaraine dye in water with nanomolar affinity and large turn-on fluorescence

Abstract

A supramolecular dye-capture system comprising anionic amidosquaraine guest and macrocyclic tetralactam host exhibits nanomolar affinity and “turn on” visible fluorescence. Utility is demonstrated with a new fluorescent assay for liposome leakage induced by the biomedically important enzyme phospholipase A2.

Graphical abstract: Supramolecular capture of highly polar amidosquaraine dye in water with nanomolar affinity and large turn-on fluorescence

Supplementary files

Article information

Article type
Communication
Submitted
07 Sept. 2021
Accepted
25 Nov. 2021
First published
30 Nov. 2021

Chem. Commun., 2021,57, 13518-13521

Author version available

Supramolecular capture of highly polar amidosquaraine dye in water with nanomolar affinity and large turn-on fluorescence

M. Dharmarwardana, J. M. Dempsey, S. Padilla-Coley, T. S. Jarvis, K. Shi, K. M. Atkinson and B. D. Smith, Chem. Commun., 2021, 57, 13518 DOI: 10.1039/D1CC05039G

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