Issue 95, 2021

Asymmetric hydrogenation of O-/N-functional group substituted arenes

Abstract

Asymmetric hydrogenation of aromatic compounds represents one of the most straightforward synthetic methods to construct important chiral cyclic skeletons that are often found in biologically active agents and natural products. So far, the most successful examples in this field are largely limited to aromatics containing alkyl and aryl substituted groups due to the poor functional-group tolerance of hydrogenation. Direct asymmetric hydrogenation of functionalized aromatics provides enormous potential for expanding the structural diversity of reductive products of planar aromatic compounds, which is highly desirable and has not been well studied. This feature article focuses on the progress in catalytic asymmetric hydrogenation and transfer hydrogenation of O/N substituted arenes.

Graphical abstract: Asymmetric hydrogenation of O-/N-functional group substituted arenes

Article information

Article type
Feature Article
Submitted
25 Aug. 2021
Accepted
14 Okt. 2021
First published
19 Okt. 2021

Chem. Commun., 2021,57, 12741-12753

Asymmetric hydrogenation of O-/N-functional group substituted arenes

B. Shao, L. Shi and Y. Zhou, Chem. Commun., 2021, 57, 12741 DOI: 10.1039/D1CC04722A

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