Issue 90, 2021

One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors

Abstract

A straightforward and gram-scale synthesis method was developed to engineer highly sulfated hyperbranched polyglycerol bearing sulfated alkyl chains. The compounds with shorter alkyl chains showed multivalent virustatic inhibition against herpes simplex virus type 1 (HSV-1), similar to heparin. In contrast, the compound with the longest alkyl chains irreversibly inhibited the virus.

Graphical abstract: One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors

Supplementary files

Article information

Article type
Communication
Submitted
24 Aug. 2021
Accepted
08 Okt. 2021
First published
21 Okt. 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2021,57, 11948-11951

One-pot gram-scale synthesis of virucidal heparin-mimicking polymers as HSV-1 inhibitors

V. Ahmadi, C. Nie, E. Mohammadifar, K. Achazi, S. Wedepohl, Y. Kerkhoff, S. Block, K. Osterrieder and R. Haag, Chem. Commun., 2021, 57, 11948 DOI: 10.1039/D1CC04703E

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