Issue 64, 2021

Selective, radical-free activation of benzylic C–H bonds in methylarenes

Abstract

We report rare examples of exclusive benzylic C–H oxidative addition in industrially important methylarenes using simple η4-arene iridium complexes. Mechanistic studies showed that coordinatively unsaturated η2-arene intermediates are responsible for the selective activation of benzylic, not aromatic C–H bonds and formation of stable benzyl complexes after trapping with a phosphine ligand.

Graphical abstract: Selective, radical-free activation of benzylic C–H bonds in methylarenes

Supplementary files

Article information

Article type
Communication
Submitted
28 Jūn. 2021
Accepted
13 Jūl. 2021
First published
13 Jūl. 2021
This article is Open Access
Creative Commons BY license

Chem. Commun., 2021,57, 7894-7897

Selective, radical-free activation of benzylic C–H bonds in methylarenes

A. P. Y. Chan, M. Jakoobi, C. Wang, Y. Tian, N. Halcovitch, R. Boulatov and A. G. Sergeev, Chem. Commun., 2021, 57, 7894 DOI: 10.1039/D1CC03445F

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