Issue 67, 2021

Electrochemical trifluoromethylation/cyclization for the synthesis of isoquinoline-1,3-diones and oxindoles

Abstract

Herein, we describe a protocol for electrochemical cathode reduction to generate trifluoromethyl radicals. The trifluoromethylation reagent (IMDN-SO2CF3) used in this strategy is inexpensive and easy to obtain, and the reaction can be conducted efficiently without the addition of additional redox reagents. Using this strategy, we achieved electrochemical trifluoromethylation/cyclization for the synthesis of isoquinoline-1,3-diones and oxindoles. This protocol has good functional group tolerance and a broad substrate scope.

Graphical abstract: Electrochemical trifluoromethylation/cyclization for the synthesis of isoquinoline-1,3-diones and oxindoles

Supplementary files

Article information

Article type
Communication
Submitted
25 Jūn. 2021
Accepted
22 Jūl. 2021
First published
23 Jūl. 2021

Chem. Commun., 2021,57, 8284-8287

Electrochemical trifluoromethylation/cyclization for the synthesis of isoquinoline-1,3-diones and oxindoles

Y. Guo, R. Wang, H. Song, Y. Liu and Q. Wang, Chem. Commun., 2021, 57, 8284 DOI: 10.1039/D1CC03389A

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