Issue 55, 2021

Easy access to drug building-blocks through benzylic C–H functionalization of phenolic ethers by photoredox catalysis

Abstract

A visible light-mediated photocatalyzed CC-bond forming method for the benzylic C–H functionalization of phenolether containing synthetic building blocks based on a radical-cation/deprotonation strategy is reported. This method allows the mild, selective generation of benzyl radicals in phenolic complex molecules and drug-like compounds, providing new entries in synthetic and medicinal chemistry.

Graphical abstract: Easy access to drug building-blocks through benzylic C–H functionalization of phenolic ethers by photoredox catalysis

Supplementary files

Article information

Article type
Communication
Submitted
02 Apr. 2021
Accepted
10 Jūn. 2021
First published
10 Jūn. 2021

Chem. Commun., 2021,57, 6756-6759

Easy access to drug building-blocks through benzylic C–H functionalization of phenolic ethers by photoredox catalysis

T. Brandhofer, M. Stinglhamer, V. Derdau, M. Méndez, C. Pöverlein and O. García Mancheño, Chem. Commun., 2021, 57, 6756 DOI: 10.1039/D1CC01756J

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